题目：MetabolomicalterationsassociatedwithBeh?et’sdisease
作者：WenjieZheng,etl.
单位：DepartmentofRheumatologyandClinicalImmunology,KeyLaboratoryofRheumatologyandClinicalImmunology,PekingUnionMedicalCollegeHospital,PekingUnionMedicalCollegeandChineseAcademyofMedicalSciences,MinistryofEducation,Beijing,China.
发表时间：Sep24,
期刊名称：ArthritisResTher
影响因子：4.56
核心亮点：
1.UsingmetabonomicsforthefirsttimetoexplorethepotentialdiagnosticmarkersofBD.首次使用代谢组学方法探索BD的潜在诊断标记。
2．ThealteredlevelsofPCsandPUFAsmaybeindicativeofthediagnosisofBD.Twon-6fattyacids,LAandAA,mayprovideinsightintotherapeuticeffects.PCs和PUFAs水平的改变可能预示着BD的诊断。两种n-6脂肪酸LA和AA可提供对治疗效果的深入了解。
思路与方法：
1.根据研究目的确定主要探究对象。
2.人群分组。
3.相关特征统计研究。
摘要：
Background
ThediagnosisofBeh?et’sdisease(BD)remainschallengingduetothelackofdiagnosticbiomarkers.ThisstudyaimstoidentifypotentialserummetabolitesassociatedwithBDanditsdiseaseactivity.
Methods
Medicalrecordsandserumsamplesof24pretreatedBDpatients,12post-treatedBDpatients,andage-matchedhealthycontrols(HC)werecollectedformetabolomicsandlipidomicsprofilingusingUPLC-QTOF-MSandUPLC-QTOF-MSEapproaches.Additionally,serumsamplesfromanindependentcohortofBDpatients,diseasecontrolsincludingrheumatoidarthritis(RA),systemiclupuserythematosus(SLE),Takayasu’sarteritis(TA),Crohn’sdisease(CD)patients,andHCwerecollectedforfurthervalidationoftwopotentialbiomarkersusingUPLC-QTOFMSanalysis.
Results
Unsupervisedprincipal
